Holy Rollers is inspired by actual events in the late nineties, when Hasidic Jews were recruited as mules to smuggle ecstasy from Europe into the United States. Sam Gold (Jesse Eisenberg), a young Hasid from an Orthodox Brooklyn community, is following the path his family has chosen with a pending arranged marriage and becoming a Rabbi. A charming neighbor, Yosef Zimmerman (Justin Bartha), senses Sam’s resistance and propositions him to transport ‘medicine’ for Jackie (Danny A. Abeckaser), an Israeli dealer, and Rachel (Ari Graynor), Jackie’s girlfriend. Sam quickly demonstrates his business acumen to his bosses, who instantly take Sam under their wing, and into the exciting worlds of Manhattan and Amsterdam nightlife. Sam falls deeper into their cavalier lifestyle, even experimenting with ecstasy, and falling for Rachel. As the business grows, Sam’s double life begins to rip his family apart, while the community starts to suspect his illegal activities. Sam slowly comes to realize the façade behind the easy money and parties. Caught between life as a smuggler and the path back to God, Sam goes on the run, forced to make a fatal decision that could bring the entire operation crashing down.